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Enhanced left ventricular systolic function early in type 2 diabetic mice: clinical implications

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

Maricela Reyes

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

Daniel Escobedo

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

Gregory L Freeman

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

Mark E Steinhelper

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

Marc D Feldman

Departments of Medicine and Physiology, University of Texas Health Science Center, San Antonio, Texas, US

It is unclear whether the increase in availability of substrates for energy production in diabetes can lead to enhanced systolic function early in the disease, before the onset of structural changes to the myocardium. To examine this issue, BKS. Cg-m +/+ Lepr db (db/db) mice with type 2 diabetes and wild type controls had left ventricular pressure-volume relationships determined in situ. We demonstrated that the db/db mice, when compared to their wild type controls, generated greater left ventricular pressure and an enhancement of left ventricular systolic function based on enhanced power/EDV, positive dP/dt, preload recruitable stroke work, dP/dt — EDV relationship, and curvilinear end-systolic elastance. This enhancement in systolic function occurred despite the db/db mice having greater body weight, but similar preload (end-diastolic volume) and afterload (effective arterial elastance).

We postulate that the previously described enhancement in renal glomerular filtration rate seen early in type 2 diabetes may be in part due to enhanced left ventricular systolic function early in this disease.

Key Words: type 2 diabetes • left ventricular pressure-volume relationships • systolic function • haemodynamics • mouse models of diabetes

Diabetes and Vascular Disease Research, Vol. 1, No. 2, 89-94 (2004)
DOI: 10.3132/dvdr.2004.013


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