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Diabetes and Vascular Disease Research
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Pathobiology and cell interactions of platelets in diabetes

Bernd Stratmann

Herz- und Diabeteszentrum NRW, Georgstraβe 11, 32545 Bad Oeynhausen, Germany

Diethelm Tschoepe

Herz- und Diabeteszentrum NRW, Georgstraβe 11, 32545 Bad Oeynhausen, Germany

Diabetes is a well-recognised risk factor for atherosclerotic cardiovascular disease and in fact most diabetic patients die from vascular complications. The Diabetes Control and Complications Trial (DCCT) and the UK Prospective Diabetes Study (UKPDS) indicate a consistent relationship between hyperglycaemia and the incidence of chronic vascular complications in patients with diabetes. Platelets are essential for haemostasis, and abnormalities of platelet function may cause vascular disease in diabetes. Diabetic patients have hyperreactive platelets with exaggerated adhesion, aggregation and thrombin generation. In summary, the entire coagulation cascade is dysfunctional in diabetes.

This review provides a comprehensive overview of the physiological role of platelets in maintaining haemostasis and of the pathophysiological processes that contribute to platelet dysfunction in diabetes and associated cardiovascular diseases, with special emphasis on proteomic approaches and leukocyte-platelet cross-talk.

Key Words: platelets • diabetes • endothelial dysfunction • thrombosis • vascular risk

Diabetes and Vascular Disease Research, Vol. 2, No. 1, 16-23 (2005)
DOI: 10.3132/dvdr.2005.001
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Diabetes Care, April 1, 2009; 32(4): 525 - 527.
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