Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Diabetes and Vascular Disease Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Asfandiyarova, N.
Right arrow Articles by Ryazantsev, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asfandiyarova, N.
Right arrow Articles by Ryazantsev, V.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diabetes
*Stroke
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Risk factors for stroke in type 2 diabetes mellitus

Nailya Asfandiyarova

Central District Hospital Sasovo, Ryazan Region, Russia

Nina Kolcheva

Central District Hospital Sasovo, Ryazan Region, Russia

Igor Ryazantsev

Central District Hospital Sasovo, Ryazan Region, Russia

Vladimir Ryazantsev

Central District Hospital Sasovo, Ryazan Region, Russia

Stroke is a serious complication of diabetes but the risk factors for stroke in these patients are not fully defined.

The aim of this retrospective study was to investigate the risk factors for stroke in patients with type 2 diabetes mellitus (T2DM). The group comprised 208 patients with T2DM, and the mean duration of follow-up was seven years (range 4–11 years). The incidence of stroke was investigated according to lymphocyte proliferation in response to insulin.

Using cimetidine to inhibit cells with histamine receptors and indometacin to inhibit prostaglandin-synthesising cells, a higher incidence of stroke was found in patients with indirect cell-mediated immunity to insulin.

Therefore, one of the risk factors for stroke in patients with T2DM is high activity of cells with histamine receptors and prostaglandin-synthesising cells. These cells suppress cell-mediated immunity to insulin and may have a role in promoting the development of insulin resistance.

Key Words: type 2 diabetes mellitus • stroke • risk factors • cell-mediated immunity • insulin • prostaglandin • histamine

Diabetes and Vascular Disease Research, Vol. 3, No. 1, 57-60 (2006)
DOI: 10.3132/dvdr.2006.009
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?