Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Diabetes and Vascular Disease Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Lee, J. M.
Right arrow Articles by Choudhury, R. P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, J. M.
Right arrow Articles by Choudhury, R. P
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus

Justin MS Lee

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Cheerag Shirodaria

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Clare E Jackson

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Matthew D Robson

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Charalambos Antoniades

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Jane M Francis

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Frank Wiesmann

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Keith M Channon

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Stefan Neubauer

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Robin P Choudhury

Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.

Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10-3 vs. 3.5 x 10-3 mmHg-1, p<0.01), faster PWV (8.8 vs., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs. 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy.

Key Words: magnetic resonance imaging • coronary artery disease • diabetes • distensibility • endothelial function • atherosclerosis

Diabetes and Vascular Disease Research, Vol. 4, No. 1, 44-48 (2007)
DOI: 10.3132/dvdr.2007.005
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?