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Diabetes and Vascular Disease Research
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Influence of metabolic risk factors on the presence of carotid artery disease in patients with type 2 diabetes and coronary artery disease

Marijan Bosevski

Institute for Heart Disease, Medical School Skopje, Vasil Gorgov 2049, Skopje, Macedonia.

Vladimir Borozanov

Institute for Heart Disease, Medical School Skopje, Vasil Gorgov 2049, Skopje, Macedonia.

Ljubica Georgievska-Ismail

Institute for Heart Disease, Medical School Skopje, Vasil Gorgov 2049, Skopje, Macedonia.

The aim of the study was to evaluate the prevalence of carotid artery disease in type 2 diabetes patients with coronary artery disease, and to establish the influence of metabolic factors on its occurrence.

In all, 145 patients (aged 59.85±8.43 years, diabetes duration 8.89±6.29 years) were randomly selected in a cross-sectional study. Carotid ultrasound was used for evaluation of the presence of carotid plaque (CP) and stenosis (CS). A logistic regression model was constructed to define the influence of risk factors - arterial hypertension, systolic blood pressure, weight, waist to hip ratio, high blood glucose and plasma lipid levels.

Carotid artery disease was present in these patients with a prevalence of 81.9% for CP, 25.2% for unilateral CS and 13.5% for bilateral CS. The low-density lipoprotein (LDL) cholesterol level was an independent predictor for CS (OR 1.936; 95% CI 1.241-3.026). Non-high density lipoprotein (HDL) cholesterol (OR 1.374; 95% CI 1.035-1.825) and glycaemia (OR 1.214; 95% CI 1.022-1.442) were predictors for carotid plaque.

Key Words: carotid artery disease • type 2 diabetes • risk factors • metabolic syndrome • non-high density lipoprotein cholesterol • low-density lipoprotein cholesterol • glycaemia

Diabetes and Vascular Disease Research, Vol. 4, No. 1, 49-52 (2007)
DOI: 10.3132/dvdr.2007.006
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M. Bosevski
Interplay of Vascular Phenotype and Metabolic Phenotype in Populations With or Without Type 2 Diabetes
Stroke, November 1, 2008; 39(11): e175 - e175.
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