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Intracoronary ultrasound examinations reveal significantly more advanced coronary atherosclerosis in people with type 1 diabetes than in age- and sex-matched non-diabetic controlsDepartment of Pediatrics, and Helse Øst Centre for Health Services; Akershus University Hospital, Lørenskog, Norway.
Cardiovascular Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Ulleval University Hospital, Department of Cardiac Radiology and Intervention, Oslo, Norway.
Ulleval University Hospital, Department of Cardiology, Oslo, Norway.
Aker University Hospital, Department of Endocrinology, Oslo, Norway.
Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Department of Pediatrics, Ulleval University Hospital and Faculty Division Ulleval, Oslo, Norway. Aims/hypothesis: The extent of coronary atherosclerosis is significantly more advanced in symptomatic type 1 diabetes patients than in symptomatic non-diabetic patients. Whether this difference exists between asymptomatic individuals with diabetes and controls is not documented. In vivo imaging techniques allow quantification of the difference at a preclinical stage. Methods: The degree of coronary atherosclerosis in early onset type 1 diabetes patients without symptoms of cardiovascular disease was compared with that of age- and sex-matched controls. Intracoronary ultrasound (IVUS) examinations were performed to determine the degree of atherosclerosis. The mean age of the patients was 43 years (35–58), they had a mean duration of disease of 30 (23–39) years and the diagnosis of type 1 diabetes was made at a mean age of 12.5 years. The controls were people with transplanted hearts; donors were sex- and age-matched and had a mean age of 43 (35–58) years.
Results: The degree of subclinical coronary atherosclerosis was significantly more severe in type 1 diabetes patients than in controls. This was the case for all parameters measured. The mean plaque area was Conclusions/interpretation: Asymptomatic individuals with type 1 diabetes have significantly more advanced sub-clinical coronary atherosclerosis than controls. Coronary atherosclerosis in type 1 diabetes develops at an early age.
Key Words: Type 1 diabetes • atherosclerosis • IVUS
Diabetes and Vascular Disease Research, Vol. 4, No. 1,
62-65 (2007) This article has been cited by other articles:
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40% in 71% (54/76) of diabetic arteries as opposed to 33% (25/76) of arteries from controls (p<0.0001). The mean plaque thickness was 0.59±0.38 mm vs. 0.44±0.30mm in controls (p<0.0001). The mean lumen area was 8.6±3.8mm2 in type 1 diabetes and 12.1±4.3 mm2 in controls (p<0.0001). 
