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Diabetic macro- and microvascular disease in type 2 diabetes

St-Luc Academic Hospital, UCL-54-74, Tour Claude Bernard + 1, 1200 Brussels, Belgium.

Before a patient develops overt type 2 diabetes mellitus, there is typically a prolonged period of patho-physiological change. In the common form of type 2 diabetes mellitus, there are years of insulin resistance, initially compensated by increased beta cell function, then impaired glucose tolerance develops, and finally type 2 diabetes. We know from studies such as the United Kingdom Prospective Diabetes Study (UKPDS) and the Belfast study that loss of beta cell function and insulin resistance are usually relentless.^{1, 2} Thus, therapy to reduce blood glucose has to be gradually increased with time for patients with diabetes. What is less well known is that every person has a different slope for beta cell function loss which intersects with insulin resistance.

Diabetes and Vascular Disease Research, Vol. 4, No. 2 Suppl, S7-S11 (2007)
DOI: 10.3132/dvdr.2007.019


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