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Diabetes and Vascular Disease Research
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Atherosclerosis in type 2 diabetes: a role for fibrate therapy?

George Steiner

University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 2C4.

Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated atherosclerotic disease. While statins remain the primary lipid-modifying therapy, the pharmacological profile of the fibrates suggests potential as an alternative or additional treatment for reducing the risk of atherosclerotic vascular complications in type 2 diabetes.

Key Words: atherosclerosis • dyslipidaemia • fibrates • type 2 diabetes

Diabetes and Vascular Disease Research, Vol. 4, No. 4, 368-374 (2007)
DOI: 10.3132/dvdr.2007.067
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