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Diabetes and Vascular Disease Research
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Aminoterminal pro-brain natriuretic peptide (NT-proBNP) and sleep-disordered breathing in morbidly obese females: a cross-sectional study

Juan Ybarra

Instituto de Cardiología y Medicina Avanzada (ICAMED), Centro Médico Teknon, C/ Vilana 12, 08021 Barcelona, Spain.

Francesc Planas

Instituto de Cardiología y Medicina Avanzada (ICAMED), Centro Médico Teknon, C/ Vilana 12, 08021 Barcelona, Spain.

Jose M Pou

Servicio de Endocrinología y Nutrición, Hospital de Sant Pau, UAB, Barcelona, Spain.

Sleep-disordered breathing (SDB) is often encountered in morbid obesity (MO) in conjunction with insulin resistance (IR). Aminoterminal pro-brain natriuretic peptide (NT-proBNP) is a promising marker for left ventricular dysfunction (LVD) in MO. We sought to explore the factors that may influence the relationships of SDB and IR with NT-proBNP in MO women.

We performed a cross-sectional pilot study involving 110 asymptomatic MO (44.5±0.7 kg/m2) young women. SDB risk was assessed using a modified version of the Berlin Questionnaire (BQ). IR was assessed using the homeostasis model assessment (HOMA) index and adiponectin levels. LVD was assessed using NT-proBNP and echocardiograms.

In this study, NT-proBNP levels and LVD increased significantly along the BQ strata. Multiple regression analysis identified BQ and log-transformed HOMA as the independent variables predicting as much as 48.0% of the variability of logNT-proBNP.

In conclusion, NT-pro-BNP levels are independently predicted by SDB and IR in asymptomatic MO women. Larger prospective studies are warranted.

Key Words: Berlin Questionnaire • diastolic dysfunction • HOMA index • morbid obesity • NT-proBNP

Diabetes and Vascular Disease Research, Vol. 5, No. 1, 19-24 (2008)
DOI: 10.3132/dvdr.2008.004
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