Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Diabetes and Vascular Disease Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Janssen, S. F
Right arrow Articles by Bruckert, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Janssen, S. F
Right arrow Articles by Bruckert, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria

Sarah F Janssen

Department of Cardiology, University Medical Centre (UMC) Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Theodorus B Twickler

Department of Vascular Medicine Academic Medical Centre Amsterdam, The Netherlands.

Christel Jublanc

Department of Endocrinology, La Pitié-Salpétrière Hospital Assistance Publique-Hôpitaux de Paris, France.

Maarten J Cramer

Department of Cardiology, University Medical Centre (UMC) Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Eric Bruckert

Department of Endocrinology, La Pitié-Salpétrière Hospital Assistance Publique-Hôpitaux de Paris, France.

The objective of this study was to investigate whether patients with the metabolic syndrome (MetS) and an imbalance in cortisol metabolism express increased urinary albumin excretion compared to those patients with metabolic syndrome alone.

Seventy-four patients with MetS were evaluated using a low-dose dexamethasone suppression test (LDDST) to identify disturbed cortisol balance (cortisol levels > 50 nmol/L after LDDST). The level of albumin in the urine was also evaluated.

Disturbed cortisol balance was found in 8% of all evaluated patients with MetS. Microalbuminuria was present significantly more often (p<0.01) in those patients with MetS and an imbalance in cortisol metabolism compared with patients suffering MetS alone (urine albumin: 210 mg/L vs. 26 mg/L, respectively, p<0.01).

A substantial percentage of patients with MetS had inappropriate cortisol homeostasis. Of importance, excretion of urinary albumin was increased in these patients. This observation may indicate that this subgroup within the MetS population has a higher cardiovascular risk and possible increased endothelial dysfunction, with a subsequent need for stricter control to prevent cardiovascular morbidity and mortality.

Key Words: disturbed cortisol balance • metabolic syndrome • microalbuminuria

Diabetes and Vascular Disease Research, Vol. 5, No. 1, 54-58 (2008)
DOI: 10.3132/dvdr.2008.010
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?