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Diabetes and Vascular Disease Research
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Blocking the renin-angiotensin-aldosterone system to prevent diabetes mellitus

Darren K McGuire

Department of Internal Medicine, the University of Texas Southwestern Medical Center at Dallas, US.

Jeffrey R Winterfield

Brigham and Women's Hospital, Boston US.

Jason A Rytlewski

Department of Internal Medicine, the University of Texas Southwestern Medical Center at Dallas, US.

Ele Ferrannini

Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy.

Type 2 diabetes mellitus (DM) is increasing around the world, and the public health impact of DM, driven largely by cardiovascular disease complications, underpins the importance of continued efforts toward primary prevention of DM. Only a few interventions have been shown to prevent DM, with none of them yet proven to improve cardiovascular risk commensurately. Accumulating evidence suggest that drugs that block the renin-angiotensin-aldosterone system (RAAS), many of which have proven cardiovascular disease (CVD) benefit, also have favourable effects on parameters of glucose metabolism and incident diabetes. Here we review the evidence accumulated to date from animal studies, clinical mechanistic studies and clinical trials regarding the effect of RAAS inhibition and incident DM.

Key Words: angiotensin-converting enzyme (ACE) inhibitor • angiotensin receptor blocker (ARB) • diabetes • prevention • renin-angiotensin-aldosterone system

Diabetes and Vascular Disease Research, Vol. 5, No. 1, 59-66 (2008)
DOI: 10.3132/dvdr.2008.011
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