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The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism

Institut Pasteur de Lille, 1, rue Calmette, BP 245, F-59019 Lille, France

Bart Staels

Université de Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques et Faculté de Medecine, Lille, F-59019 France.

Circadian rhythms are normal variations in physiological processes that occur over the period of a day. These rhythms are essential for the organism since they allow anticipatory metabolic regulations to prepare for the up-coming feeding or rest period. Disturbances of the biological clock predispose to metabolic disorders such as dyslipidaemia, insulin resistance and obesity. Moreover, certain pathological events, such as cardiovascular accidents (myocardial infarction, stroke) occur more frequently at specific times of the day. The nuclear receptors Rev-erb and ROR are clock components involved in the regulation of the core clock circuitry. They are also important regulators of lipid and lipoprotein metabolism, adipogenesis and vascular inflammation. Moreover, they cross-talk with several other nuclear receptors controlling energy homeostasis. Therefore, Rev-erb and ROR may play a central role in the coordination of metabolic processes and circadian outputs.

Key Words: biological clock • cardiovascular disease • Circadian rhythm • metabolic disorders • nuclear receptor • Rev-erb • ROR.

Diabetes and Vascular Disease Research, Vol. 5, No. 2, 82-88 (2008)
DOI: 10.3132/dvdr.2008.0014


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