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Diabetes and Vascular Disease Research
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Association of glycosylated haemoglobin level and diabetes mellitus duration with the severity of coronary artery disease

Tahir Saleem

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Kazim Hameedullah Mohammad

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Moataz M Abdel-Fattah

Department of Preventive Medicine (research unit), Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Abdul Hafeez Abbasi

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Diabetes mellitus (DM) is known to cause microvascular and possibly macrovascular complications. This study was performed to find the association between glycosylated haemoglobin (HbA1C) level and the severity of coronary artery disease. One hundred and ten consecutive patients admitted to hospital with acute myocardial infarction were studied. Seventy-eight patients (70.9%) had DM, 73 (93.58%) had HbA1C > 7%, 52 (47.3%) were hypertensive, 19 (17.3%) had a history of smoking and 37 (33.6%) had raised cholesterol. Coronary angiography was carried out in 87 (79.1%) patients and the severity of disease was assessed using the Gensini score. The mean Gensini score was 53.36±36.94 and the mean HbA1C was 8.4±2.39%. There was a significant association between Gensini score and DM (p=0.003) and between Gensini score and hypertension (p=0.018). HbA1C (r=0.427, p=0.001) and duration of DM (r=0.362, p=0.004) had a positive linear correlation with the Gensini score. Multiple regression analysis showed HbA1C to be an independent factor that influenced the Gensini score (p=0.021).

Key Words: diabetes mellitus • Gensini score • HbA1C • severity of coronary artery disease

Diabetes and Vascular Disease Research, Vol. 5, No. 3, 184-189 (2008)
DOI: 10.3132/dvdr.2008.030
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