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Diabetes and Vascular Disease Research
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Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings

Antonio Ceriello

Warwick Medical School, Clinical Science Research Institute, Clinical Science Building, University Hospital – Walsgrave Campus, Clifford Bridge Road, Coventry, CV2 2DX, UK.

High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.

Key Words: endothelial dysfunction • oxidative stress • postprandial hyperglycaemia

Diabetes and Vascular Disease Research, Vol. 5, No. 4, 260-268 (2008)
DOI: 10.3132/dvdr.2008.038
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