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Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men

Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, DK 8000, Aarhus C, Denmark.

Abel Lopez-Bermejo

Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona "Dr Josep Trueta", Girona; and CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/0003/010), Carreterra de Francia s/n, 17007 Girona, Spain.

Judit Bassols

Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona "Dr Josep Trueta", Girona; and CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/0003/010), Carreterra de Francia s/n, 17007 Girona, Spain.

Joan Vendrell

Endocrinology and Research Unit. Hospital Universitari Joan XXIII from Tarragona, Rovira i Virgili University, c/Mallafre Guasch s/n, 43007 Tarragona, Spain.

Wifredo Ricart

Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona "Dr Josep Trueta", Girona; and CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/0003/010), Carreterra de Francia s/n, 17007 Girona, Spain.

Jose M Fernandez-Real

Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona "Dr Josep Trueta", Girona; and CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/0003/010), Carreterra de Francia s/n, 17007 Girona, Spain.

Recently, soluble CD36 (sCD36) levels were reported to be elevated in type 2 diabetes, and to be tightly correlated with insulin resistance. Our aim was to obtain further insight into the relationship between insulin sensitivity, low-grade inflammation and sCD36.

We studied glucose-tolerant (n=90) and glucose-intolerant (n=57) moderately obese men. Insulin sensitivity was measured by the frequent sample intravenous glucose tolerance test, and sCD36 by an in-house ELISA assay.

In glucose-intolerant subjects, sCD36 was negatively associated with insulin sensitivity and positively with interleukin-6 (IL-6), fasting glucose, fasting triglycerides, fat-free mass and platelet count. On multiple linear regression analyses, insulin sensitivity contributed 22% of sCD36 variance, independent of age, body mass index (BMI) and IL-6, in glucose-intolerant subjects. The level of sCD36 in subjects with glycosylated haemoglobin (HbA_1C) above the mean was higher than in those with HbA_1C values below the mean.

Insulin sensitivity is a predictor of sCD36 in men with impaired glucose tolerance. IL-6 is related to sCD36 but does not predict sCD36 independent of insulin sensitivity and BMI.

Key Words: diabetes • glucose intolerance • insulin resistance • low grade inflammation • obesity • risk marker • sCD36

Diabetes and Vascular Disease Research, Vol. 6, No. 1, 15-20 (2009)
DOI: 10.3132/dvdr.2009.003


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