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Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA)

Centre for Eye Research Australia, University of Melbourne 32 Gisborne Street, East Melbourne, Victoria 3002, Australia

Tien Yin Wong

Centre for Eye Research Australia, University of Melbourne 32 Gisborne Street, East Melbourne, Victoria 3002, Australia

FM Amirul Islam

Centre for Eye Research Australia, University of Melbourne 32 Gisborne Street, East Melbourne, Victoria 3002, Australia

Ronald Klein

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N. Walnut St. Room 450 WARF Madison, WI 53726, US.

Barbara EK Klein

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N. Walnut St. Room 450 WARF Madison, WI 53726, US.

Mary Frances Cotch

Division of Epidemiology and Clinical Applications, National Eye Institute, NIH, 5635 Fishers Lane, Bethesda, MD 20892–9301, US.

Alicia J Jenkins

The University of Melbourne, Department of Medicine, St Vincent's, Level 4, Clinical Sciences Building, Cnr Princes & Regent Streets, Fitzroy Melbourne, Victoria 3065, Australia.

Steven Shea

Departments of Medicine and Epidemiology, Schools of Medicine and Public Health, Columbia University, 630 W 168th Street, New York, NY 10032, US.

Jie Jin Wang

Objective

To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes.

Research design and methods

In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy.

Results

After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident.

Conclusion

The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.

Key Words: diabetic retinopathy • NMR-lipoprotein • retinal photography • type 2 diabetes

Diabetes and Vascular Disease Research, Vol. 6, No. 1, 40-42 (2009)
DOI: 10.3132/dvdr.2009.008


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