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Diabetes and Vascular Disease Research
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Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease — do we need to screen our patients?

Aled W. Roberts

Centre for Endocrine and Diabetes Sciences,Wales College of Medicine, Cardiff University, Cardiff, UK

Andrew L. Clark

Department of Academic Cardiology, University of Hull, Kingstonupon-Hull, UK

Klaus K. Witte

Division of Cardiovascular and Diabetes Research, LIGHT laboratories, University of Leeds, Leeds, UK, k.k.witte{at}leeds.ac.uk

The metabolic syndrome and its components, glucose intolerance, T2DM, hypertension, dyslipidaemia and obesity are increasingly common. Patients with the metabolic syndrome have a higher prevalence of chronic heart failure (CHF) and, once diagnosed, CHF in such subjects is associated with a higher mortality than in those without this co-morbidity. However, early diagnosis of LV systolic dysfunction and symptomatic heart failure may prevent deterioration of heart failure and improve prognosis. The aim of this article is to summarise the prevalence of CHF in people with obesity, hypertension and T2DM, and to review how each co-morbid condition might predispose to and complicate the clinical diagnosis of CHF.

Key Words: obesity • diabetes • hypertension • heart failure

Diabetes and Vascular Disease Research, Vol. 6, No. 3, 153-163 (2009)
DOI: 10.1177/1479164109338774
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