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Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis

Division of Endocrinology,The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China

Guoyu Tong

Division of Endocrinology,The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China

Wei Xu

Division of Endocrinology,The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China

Jiajia Pan

Division of Endocrinology,The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China

Kathy Ryan

Division of Endocrinology, Diabetes and Nutrition Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Rongze Yang

Division of Endocrinology, Diabetes and Nutrition Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Alan R. Shuldiner

Division of Endocrinology, Diabetes and Nutrition Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Da-Wei Gong

Division of Endocrinology, Diabetes and Nutrition Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Dalong Zhu

Division of Endocrinology,The Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China, zhudldr{at}gmail.com

Objective: Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients.

Method: In this study,we investigated the changes of CRP and inflammation-related adipokines (SAA,IL-6,TNF and adiponectin) in 23 type 2 diabetic patients with atherosclerosis who received statin therapy, and 20 diabetic patients with atherosclerosis and 14 diabetic patients without atherosclerosis who did not receive statin therapy for a period of three months.

Results: By the end of the simvastatin treatment (40 mg, daily), LDL-cholesterol was decreased by 16.7% and HDL-cholesterol was increased by 31.9%. SAA, CRP, TNF and IL-6 levels were decreased by 31.8%, 66.2%, 53.9% and 14%, respectively and adiponectin was increased by 59.6%, compared with the baseline levels. Interestingly, the decrease of SAA was positively correlated with that of LDL-cholesterol but negatively with HDL-cholesterol during statin treatment. Among the adipokines, the decrease of SAA was positively correlated with TNF (r = 0.50, p = 0.016).

Conclusion: The results suggest that adipokines may be differentially regulated and independent of cholesterol changes and that adipokines may be a mediator, and the adipose tissue may be a target of statins’ anti-inflammatory effect.

Key Words: statin • anti-inflammation • adipokines • atherosclerosis • type 2 diabetes

Diabetes and Vascular Disease Research, Vol. 6, No. 4, 262-268 (2009)
DOI: 10.1177/1479164109339966


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