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Diabetes and Vascular Disease Research
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Sex-based differences in the association between duration of type 2 diabetes and heart rate variability

Robert P. Nolan

Behavioral Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada, rnolan{at}uhnres.utoronto.ca, Faculty of Medicine, University of Toronto,Toronto, Ontario, Canada

Susan M. Barry-Bianchi

Behavioral Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada

Adriana E. Mechetiuc

Behavioral Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada

Maggie H. Chen

Behavioral Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada

We examined the association between heart rate variability (HRV) and duration of type 2 diabetes among 155 female and 106 male subjects: mean±SD for duration=49.6±65.6 and 57.3±77.1 months, respectively, p=0.38. Among males, duration of diabetes was independently and inversely associated with vagal-heart rate modulation (high frequency (HF) power, 0.15—0.40 Hz, standardised ß = -0.32, p=0.001; root mean square of successive differences between R-R intervals, ß = -0.26, p=0.006) and total R-R variability (standard deviation of normal R-R intervals, ß = -0.36, p=0.001); but not among females (p≥0.80 for each HRV index). In contrast, HF was inversely associated with age of diabetes diagnosis (ß = -0.16, p=0.04) and 10-year absolute risk for coronary heart disease (ß = -0.16, p=0.04) among female subjects. Longitudinal research is needed to establish whether risk factors for early cardiac autonomic impairment differ among men and women with type 2 diabetes.

Key Words: type 2 diabetes • duration • sex • heart rate variability • autonomic

This version was published on October 1, 2009

Diabetes and Vascular Disease Research, Vol. 6, No. 4, 276-282 (2009)
DOI: 10.1177/1479164109339965
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