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Diabetes and Vascular Disease Research
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Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians

Kaur Harsimran

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India

Arora Ajinder Pal Singh

Dr AP Singh Heart Care Centre, Amritsar, Pujab, India

Singh Guruvinder

Department of Medicine, Mata Kaulan Hospital, Amritsar, Punjab, India

Sidhu Sharda

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India

Sambyal Vasudha

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India, vasudhasambyal{at}yahoo.co.in

The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis. The present study was designed to explore the relation of plasma levels of MCP-1 to disease pathology in type 2 diabetes and coronary artery disease (CAD) patients. Fasting plasma venous samples were taken from 162 subjects divided into four groups: Patients with type 2 diabetes mellitus and CAD (n=41), type 2 diabetes patients without CAD (n=50), CAD patients with no history of diabetes (n=41) and healthy controls (n=30). Coronary risk factors such as body mass index, percentage body fat, waist/hip ratio, blood pressure and physical activity were measured using standard procedures. Plasma MCP-1 was quantitatively estimated by sandwich enzyme-linked immunoabsorbent assay (ELISA). Significant differences were observed for MCP-1 levels, percent body fat, body mass index, waist/hip ratio, systolic and diastolic blood pressure amongst the groups. MCP-1 concentration was significantly correlated with diabetes duration (p<0.001), body mass index (p<0.01), waist/hip ratio (p<0.01), systolic blood pressure (p<0.01), percentage body fat (p<0.01) and physical activity level (p<0.001). MCP-1 might serve as a marker for CAD, and its association with CAD is mainly driven by traditional coronary risk factors.

Key Words: monocyte chemoattractant protein-1 (MCP-1) • diabetes • coronary artery disease • North Indians

Diabetes and Vascular Disease Research, Vol. 6, No. 4, 288-290 (2009)
DOI: 10.1177/1479164109346364
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