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Association of glycosylated haemoglobin level and diabetes mellitus duration with the severity of coronary artery disease

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Kazim Hameedullah Mohammad

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Moataz M Abdel-Fattah

Department of Preventive Medicine (research unit), Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Abdul Hafeez Abbasi

Department of Cardiac Sciences, Al Hada Armed Forces Hospital, Taif, PO Box 1347, Zip Code 21944, Kingdom of Saudi Arabia.

Diabetes mellitus (DM) is known to cause microvascular and possibly macrovascular complications. This study was performed to find the association between glycosylated haemoglobin (HbA_1C) level and the severity of coronary artery disease. One hundred and ten consecutive patients admitted to hospital with acute myocardial infarction were studied. Seventy-eight patients (70.9%) had DM, 73 (93.58%) had HbA_1C > 7%, 52 (47.3%) were hypertensive, 19 (17.3%) had a history of smoking and 37 (33.6%) had raised cholesterol. Coronary angiography was carried out in 87 (79.1%) patients and the severity of disease was assessed using the Gensini score. The mean Gensini score was 53.36±36.94 and the mean HbA_1C was 8.4±2.39%. There was a significant association between Gensini score and DM (p=0.003) and between Gensini score and hypertension (p=0.018). HbA_1C (r=0.427, p=0.001) and duration of DM (r=0.362, p=0.004) had a positive linear correlation with the Gensini score. Multiple regression analysis showed HbA_1C to be an independent factor that influenced the Gensini score (p=0.021).

Key Words: diabetes mellitus • Gensini score • HbA1C • severity of coronary artery disease

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Diabetes and Vascular Disease Research, Vol. 5, No. 3, 184-189 (2008)
DOI: 10.3132/dvdr.2008.030


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Saleem, T. Articles by Abbasi, A. H. Search for Related Content PubMed PubMed Citation Articles by Saleem, T. Articles by Abbasi, A. H. Pubmed/NCBI databases Medline Plus Health Information Coronary Artery Disease Diabetes Social Bookmarking                         What's this?